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Year : 2021  |  Volume : 15  |  Issue : 1  |  Page : 4-7

Fentanyl-induced respiratory depression: A narrative review on the possible single-nucleotide polymorphism

1 Department of Anesthesiology, Sri Ramakrishna Hospital, Coimbatore, Tamil Nadu, India
2 Department of Biotechnology, PSG College of Technology, Coimbatore, Tamil Nadu, India

Correspondence Address:
Dr. Prabha Udayakumar
Department of Anesthesiology, Sri Ramakrishna Hospital, Coimbatore - 641 044, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aer.aer_94_21

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Opioid-related respiratory depression is a serious clinical problem as it can cause multiple deaths and anoxic brain injury. Genetic variations influence the safety and clinical efficacy of fentanyl. Pharmacogenetic studies help in identifying single-nucleotide polymorphisms (SNPs) associated with fentanyl causing respiratory depression and aid clinician in personalized pain medicine. This narrative review gives an insight of the common SNPs associated with fentanyl.

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