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Year : 2011  |  Volume : 5  |  Issue : 2  |  Page : 134-137

Palonosetron and palonosetron plus dexamethasone to prevent postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A prospective, randomized, double-blind comparative study

1 Department of Anesthesiology, Calcutta National Medical College (CNMC), Kolkata, India
2 Department of Anesthesiology, Bangur Institute of Neurology (BIN), Kolkata, India

Correspondence Address:
Anirban Pal
43/6/5 Jheel Road, Kolkata - 700 031, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0259-1162.94751

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Background: Laparoscopic cholecystectomy (LC) is associated with a high risk of postoperative nausea and vomiting (PONV). Palonosetron is a newer 5HT3 receptor antagonist, which is routinely used in our institution to prevent PONV in patients scheduled for LC, under general anesthesia (GA). We formulated this study to find out whether the palonosetron and dexamethasone combination will be a better choice than palonosetron alone in the prevention of PONV. Materials and Methods: Sixty American Society of Anesthesiologists (ASA) physical status I and II patients, scheduled for LC under GA, were randomized to receive either palonosetron or a combination of palonosetron and dexamethasone. The number of complete responders (no emesis, no requirement of rescue anti-emetic medication) and the four-point nausea score was recorded at 2, 6, 24, 48 h postoperatively and the data was analyzed statistically. Results: The number of complete responders, as well as the nausea score, did not vary significantly (P=0.718) between the two groups over the 48-h postoperative period. Conclusions: The palonosetron and dexamethasone combination was not more effective than palonosetron alone in the prevention of PONV, in patients undergoing LC under GA.

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